The outlook, however, is not entirely bleak: Langston believes that there is certainly "a good chance of finding a cause of Parkinson's in the next 10 years". "These cells - the pigmented neurons in the substantia nigra of the brain - produce dopamine, a chemical messenger responsible for transmitting signals within the brain," Langston explains. Before the English doctor James Parkinson described its symptoms in 1817, people called it the "shaking palsy". The Michael J Fox Foundation, which supports research into Parkinson's, estimates that while "at least one million people in the United States have Parkinson's, many of them, perhaps half, are thought to be undiagnosed". "You can find studies that people who spend time with each other are more susceptible to Parkinson's disease and you can find the reverse," Dr Abe Lieberman, medical director for the National Parkinson Foundation in Miami, told the Sun-Times. Fox, in his television acting debut, playing Jamie, the 12-year-old younger nephew of Leo (Brent Carver). Fox and director Don Williams were among the four with the disease, along with a writer and a cameraman. "You might trace all the people in a cluster to one apartment block," Langston explains, "then discover that it was torn down in 1982 and made into a mall." The Leo and Me news merely highlights how little we know about a disease that hits about 1% of people over the age of 50. Lucy Atkins. Did they all breathe in some environmental toxin in the studio? Original reporting and incisive analysis, direct from the Guardian every morning. Leo and Me was produced by Don Eccleston, directed by Don S. Williams and written by Marc and Susan Strange. "We were going to be called the 'Cluster Busters'. But it's intriguing, it might be something they were exposed to."[2]. This rate was 30% higher than the general population. It may, it has now emerged, have been more than that. It is, for instance, extremely difficult (and expensive) to differentiate between a cluster and a coincidence. They concluded that there was little evidence that the cause of the illness in older people (ie those over 50) could be genetic. Scientists are arguing over whether this could be classed as a "cluster" of Parkinson's cases - and if so, what could have caused it? Last edited on 8 September 2022, at 19:16, "Michael J. "If there is not enough dopamine, critical nerve cells in the brain, or neurons, start to fire out of control.". In 1998, Michael J Fox, the elfin star of the US sitcom, Spin City, lost his Peter Pan image in one startling announcement: he had, he told us, been diagnosed with Parkinson's disease . For more than a century scientists have been arguing about what causes this debilitating, degenerative brain disease. In 2002, an investigation was launched into Leo and Me after an unusual cluster of Parkinson's disease cases was noted among former cast and crew members of the show. The slowness (known as brady- kinesia) and shaking that we all recognise as a sign of Parkinson's worsen as the condition progresses (usually over a few years). Or is it all down to fate? The problem is that clusters are "incredibly difficult to investigate - you would have to do daunting research to get an answer". "We once put together a proposal to set up a team which would investigate all suspected clusters of Parkinson's across the US," Langston says. And the Michael J Fox Foundation is equally cautious, saying on its website that "most scientists believe a combination of genetic and environmental factors" are to blame. So what about Fox and the suspected Leo and Me cluster? However: "When it comes to most cases of typical older-onset Parkinson's, genetics don't look likely as an explanation.". Other investigations into the disease in mining communities have shown certain metals to be guilty parties - aluminium and manganese are the main villains. Some believe that the condition is a result of still-to-be-discovered genetic factors. Others maintain that most cases of Parkinson's are caused by the world around us: exposure, perhaps, to some kind of viral infection, or to environmental pollutants. Consequently, says Langston, "most people would currently say that the environment plays a greater role in Parkinson's than genetics". But we didn't find funding.". He told the Chicago Sun-Times that studies have found there to be an increased risk of clusters among certain workers who operate closely together - principally teachers, medical workers, loggers and miners. The department of neurology convened a "cluster committee" of experts to investigate but they could find no evidence of an environmental cause. Eventually, you find walking, talking, or doing other simple tasks extremely difficult. This article relating to a comedy television series in Canada is a stub. Fox stated, "Believe it or not, from a scientific point of view, that's not significant. [1][2][3], When asked about the cluster by Howard Stern in a September 25, 2013, interview on The Howard Stern Show, Michael J. Leo and Me is a Canadian television sitcom that was produced in 1977 and aired in 1978.. And it is even more difficult to establish, from that, what could have caused the outbreak. Dr Paul Maestrone, director of scientific and medical affairs at the American Parkinson's Disease Association, emphasises that "no definitive data exists" to fully explain the causes of Parkinson's. The disease is certainly not new. However, since these genes are extremely rare, these studies by no means account for most cases of older-onset Parkinson's. Michael J Fox was startlingly unlucky to develop 'the shaking palsy' at such a young age. It starred a 15-year-old Michael J. Or did they perhaps pass the disease to each other? Fox part of B.C. There are, however, some environmental culprits that show up in study after study, says Maestrone. But if we know who's pulling the trigger we might, eventually, be able to dodge the bullets. Remaining evidence may be scarce, or patchy. Now three people who worked with him on a sitcom during the 70s have revealed they also have the disease. Dr Donald Calne, of the University of British Columbia Hospital, is treating two of the cast of Leo and Me. This is because certain cells in your brain are simply fading away. It is, says Dr JW Langston, scientific director and chief executive of the Parkinson's Institute in California, "a progressive neurodegenerative disorder characterised by stiffness of muscles, slowing down of movement and a tremor". How could he have a disease normally associated with the elderly? Can you "catch" Parkinson's? But in the beginning it can be difficult to diagnose. Fox) to live with him. Leo (Brent Carver) was a carefree, hard-living Italian adventurer who had won a large, decrepit yacht in a poker game, and had taken his orphaned nephew Jamie (Michael J. "The average time from the first symptom appearing to diagnosis is two years," says Langston. This difficulty could explain why other suspected Parkinson's clusters have remained enigmatic. Calne said, "It could be coincidence. Fox's first big TV break came with the 1970s Canadian TV sitcom Leo and Me. Fox, in his television acting debut, playing Jamie, the 12-year-old younger nephew of Leo (Brent Carver).. Leo and Me was produced by Don Eccleston, directed by Don S. Williams and written by Marc and Susan Strange. Is there a link? "If Michael J Fox's wife developed Parkinson's disease, I would pay more attention to the cluster theory.". In 1998, Michael J Fox, the elfin star of the US sitcom, Spin City, lost his Peter Pan image in one startling announcement: he had, he told us, been diagnosed with Parkinson's disease seven years previously. But then again, other investigations, going back over five generations of a family with an astonishingly high rate of Parkinson's led scientists to identify two genes that cause a particular kind of the disease. "[4] Donald Calne, a Vancouver neurologist, said the incidence of Parkinson's in society is about 1 in 300, but that four of the 125 people on the Vancouver set of Leo and Me developed the disease. To most of us this didn't seem possible. And it emerged last week that three other members of this TV crew have also been diagnosed with Parkinson's. One thing, though, is beyond debate: Fox was startlingly unlucky to develop it in his 30s. Fox - who looked about 16 years old - was in his 30s when diagnosed. The rate of Parkinson's in both types of twin was virtually the same. His "young-onset" Parkinson's, which affects those under the age of 40, accounts for only 3-4% of cases. The water table, they concluded, had been contaminated by pesticides and herbicides). The cause, of course, is not the cure. It appeared to be genetic bad luck on a grand scale. So right now, as Langston puts it, "there is no smoking gun." Leo and Me is a Canadian television sitcom that was produced in 1977 and aired in 1978. In 1999 Langston's team published a study in the Journal of the American Medical Association in which they compared instances of the condition in twins with exactly the same genetic make-up and fraternal twins. Leo's charm and good luck guided him through tricky but humorous situations and his young sidekick's adept mind helped the pair get out of trouble. Even if the building still exists, toxins once present may have dissipated. But what, exactly, in our environment could be causing it? They could, the theory goes, be exposed to more viruses than most people, and this might cause them to develop the disease. Investigations into incidences of Parkinson's in agricultural communities, for instance, have repeatedly linked high exposure to certain pesticides, herbicides and fertilisers with the disease (one Canadian study of farming communities showed that those who drank well water were dramatically more likely to develop the disease. Parkinson's 'cluster', https://en.wikipedia.org/w/index.php?title=Leo_and_Me&oldid=1109243829, This page was last edited on 8 September 2022, at 19:16. Doctors understand more about young-onset than they do older-onset Parkinson's. One theory, that has been around for years, is that Parkinson's could be caused - or perhaps triggered - by a viral infection, maybe even influenza. You can help Wikipedia by expanding it. 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