However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. As a result, less pressure is built up and your heart does not have to work as hard to pump blood. If you eat breakfast at 8:00 in the morning, wait for 2 hours or un. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Do not suddenly stop taking this medication without consulting your doctor. If you have liver disease, your body may have trouble clearing nifedipine from your blood. You may report side effects to FDA at 1-800-FDA-1088. Your doctor can tell you more. It also has other off-label indications. allergic reaction (rash; hives; swelling of the face, lips, tongue, or throat; difficulty breathing) signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds) Some people may experience side effects other than those listed. Taking your pills with a light snack or at bedtime may help reduce the nausea. This can be harmful or prevent the drug from working well. You may need to stop using the medicine for a short time. Remember that this medicine will not cure your high blood pressure, but it does help control it. Your doctor may start you on a lowered dose or a different medication schedule. Runny nose. Your doctor may increase your dose as needed. If you need surgery, tell the surgeon ahead of time that you are using nifedipine. For this drug to work well, a certain amount needs to be in your body at all times. The usual starting dose is: If a doctor prescribes it for your child, the dose will usually be lower. Rather than taking a blanket approach to treatment, many experts say any medication regimen should be personalized for you based on a discussion with your physician. You are wondering about the question why take nifedipine on empty stomach but currently there is no answer, so let kienthuctudonghoa.com summarize and list the top articles with the question. Things to remember when you fill your prescription. High blood pressure often has no symptoms. Take nifedipine even if you feel well, as you will still be getting the benefits of the medicine. The capsules are available as the brand-name drug. Remember to use it at the same time each day. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Next review due: 18 February 2025, Taking nifedipine with other medicines and herbal supplements, 10mg, 20mg, 30mg, 40mg and 60mg slow-release tablets and capsules, standard capsules or liquid 5mg, taken 3 times a day (every 8 hours), slow-release tablets or capsules 10mg, taken twice a day (every 12 hours), or 20 to 30mg, taken once a day (every 24 hours, preferably in the morning), standard capsules or liquid 20mg, taken 3 times a day (total of 60mg a day), slow-release capsules or tablets 40mg, taken twice a day, or 90mg once a day (total of 80mg or 90mg a day), 3 times a day leave out that dose and take your next dose at the usual time, twice a day take it as soon as you remember unless it is less than 4 hours until your next dose. These drugs are often used to treat similar conditions. Version: 12.01. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. It is primarily used as an antihypertensive and as an anti-anginal medication. Nifedipine can cause a severe allergic reaction. Nausea and vomiting are two of the most common symptoms of gastroparesis, most likely stemming from the sluggish emptying of the stomach. The researchers found that bedtime medication seemed to make a difference for patients as they had better nighttime blood pressure. stomach discomfort, upset, or pain. However, green tea doesn't appear to have the. FDA-approved indications include chronic stable angina, hypertension. Do you have large swings in your blood pressure? Taking medicines on an empty stomach means that you should take your pills 2 hours before you eat or 2 hours after you eat. We clearly need more data.. If you are a Mayo Clinic patient, this could Nifedipine comes as standard capsules, or more commonly as slow-release tablets or capsules. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The list of medications is seemingly endless, so it's very . Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Nifedipine is quickly absorbed when taken orally and peak blood levels occur in approximately 30 minutes. Nifedipine is a calcium channel blocker in the dihydropyridine subclass. This content does not have an English version. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Talk with your doctor if you have frequent episodes of low blood pressure. Discuss the use of grapefruit products with your doctor. Non-dipping blood pressure tends to remain high overnight. In a recent study, over half of the people taking a long acting form of Metformin for diabetes reported seeing ghost tablets in the stool. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Do not take this medicine in larger or smaller amounts or for longer than recommended. How to tell if the drug is working: If youre taking this drug to treat high blood pressure, your blood pressure level should go down. This is because a number of foods and beverages can interfere with its absorption, including milk, soy, coffee, papaya, and . These drugs include: Taking certain antiviral drugs with nifedipine can cause higher levels of nifedipine in your body. Many people using this medication do not have serious side effects. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Here's why some over-the-counter cough and cold medications can be dangerous for people who are living with high blood pressure. Levothyroxine is the second-most-prescribed drug in the U.S., with more than 102 million prescriptions in 2019. Historically, people were advised to take their pill first thing in the morning, on an empty stomach, and wait at least an hour before having breakfast. Have your blood pressure checked regularly while taking this medication. Grapefruit juice can increase the amount of certain medications in your bloodstream. Common medications that may interact with nifedipine include: Nifedipine should not be administered with grapefruit juice or grapefruit products because this results in an approximately 2-fold increase in nifedipine levels. health information, we will treat all of that information as protected health This content does not have an Arabic version. Talk to your doctor if you want to stop taking nifedipine. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Always carry your medication with you or in your carry-on bag. Calcium channel blockers such as nifedipine (Procardia) and beta blockers such as propranolol (Inderal) can also cause heartburn. Created for people with ongoing healthcare needs but benefits everyone. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Talk to your doctor if you are using marijuana (cannabis). Page last reviewed: 18 February 2022 You may need to take an extended-release tablet on an empty stomach. Whether you want a vegetarian option, a meal with meat or salmon, or low sodium condiments to use with many dishes, there's something for everyone. These may include: Vomiting. Mayo Clinic does not endorse companies or products. information submitted for this request. Antibiotics & dairy products. This site complies with the HONcode standard for trustworthy health information: verify here. ChildrenUse and dose must be determined by your doctor. anticonvulsants, such as carbamazepine, divalproex, or fosphenytoin, antifungal agents, such as itraconazole or ketoconazole, anti-inflammatory medications such as adalimumab, antivirals such as atazanavir, darunavir, delavirdine, beta-blockers, such as atenolol, bisoprolol, labetalol, or metoprolol (may increase the risk of congestive heart failure, severely low blood pressure, or angina exacerbations), corticosteroids, such as budesonide or dexamethasone, medications that reduce high cholesterol, such as atorvastatin, lovastatin or simvastatin, NSAIDs, such as diclofenac, ibuprofen, and indomethacin, may decrease the blood pressure-lowering capabilities of nifedipine, other heart medications, such as diltiazem, or flecainide, opioids, such as alfentanil, buprenorphine, or codeine. It has many uses in cardiology and is even used in pregna. What else can you do to better control your blood pressure? Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. However, the dose is usually not more than 90 mg once a day. You may report side effects to the FDA at 1-800-FDA-1088. Your doctor will write the number of refills authorized on your prescription. For children: This medication has not been studied in children. This usually means you do not need to take them as often. You may need to buy a blood pressure monitor to check your blood pressure at home. In the study, the researchers followed 19,084 patients with high blood pressure for a median of 6 years. Review/update the Why is the timing of your medication important? Swallow the tablets whole. It lowers blood pressure by relaxing the blood vessels so the heart does not have to pump as hard. Its also used to treat two types of angina (chest pain): vasospastic angina and chronic stable angina. (A spasm is a temporary, sudden narrowing of these arteries.). Nifedipine oral tablet is a prescription drug thats available as the brand-name drugs Adalat CC, Afeditab CR, and Procardia XL. In Canada - Call your doctor for medical advice about side effects. This drug should only be used if the potential benefit justifies the potential risk to the fetus. Consult your pharmacist or local waste disposal company. This could make nifedipine less effective. Examples include apalutamide, cimetidine, enzalutamide, mitotane, quinupristin/dalfopristin, St. John's wort, rifamycins (such as rifabutin, rifampin), drugs used to treat seizures (such as carbamazepine, phenytoin), among others. Some products have ingredients that could raise your heart rate or blood pressure. Peripheral edema (fluid retention in the lower limbs) occurs in one in ten people prescribed nifedipine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Canada residents can call a provincial poison control center. Heres how you can reduce your risk during the winter months. 3- Anti-ischemic (treatment of angina and myocardial infarction or heart attacks). Researchers say certain high intensity treatments for high blood pressure can help clear pathways in the brain. Other side effects not listed may also occur in some patients. You can learn more about how we ensure our content is accurate and current by reading our. Medicines that interact with nifedipine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with nifedipine. Follow the directions on your medicine label about taking this medication with or without food. Nevirapine can cause serious, life-threatening side effects. It is relatively short-acting and needs to be taken three times a day. Exercise regularly (over 150 minutes per week). Nifedipine is in a class of medications called calcium-channel blockers. Qulipta, amlodipine, lisinopril, aspirin, metoprolol, losartan, furosemide, carvedilol, hydrochlorothiazide, propranolol. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education. Talk with your doctor about which form is right for you. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Follow the directions on your medicine label about taking this medication with or without food. Follow all directions on your prescription label. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Drug information provided by: IBM Micromedex. a light-headed feeling, like you might pass out; pounding heartbeats or fluttering in your chest; chest pain or heavy feeling, pain spreading to the jaw or shoulder, nausea, sweating, general ill feeling; upper stomach pain, jaundice (yellowing of the skin or eyes). Store the extended-release tablets below 86F (30C). Dosage is based on your medical condition and response to treatment. It often rises higher during the day and falls at night when we sleep. Learn how to monitor your own blood pressure at home, and share the results with your doctor. This drug may make you dizzy. information submitted for this request. Swallow the tablets whole. Beta-blockers are used to treat many conditions. Before taking nifedipine, tell your doctor if you have kidney or liver disease, a blockage in your digestive tract (stomach or intestines), a history of stomach surgery, coronary artery disease, underactive thyroid, diabetes, or congestive heart failure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Although not all of these side effects may occur, if they do occur they may need medical attention. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Laboratory and/or medical tests (such as liver or kidney function tests, EKG) may be performed from time to time to monitor your progress or check for side effects. Call your doctor for medical advice about side effects. You will need to buy a home blood pressure monitor to do this. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. Healthline Media does not provide medical advice, diagnosis, or treatment. For people with a history of gastrointestinal blockage: There have been rare reports of gastrointestinal blockage with use of the brand-name drug Procardia XL. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Cold hands or feet. (2021). Extended-release products work like a little pump as they pass through the GI tract, slowly releasing the medication contained inside the tablet shell over a certain time period. The risk is greater during initial therapy or upwards dose titration and may be more common in those already taking beta-blockers. Do not break, crush, or chew it. health information, we will treat all of that information as protected health standard capsules or liquid - 5mg, taken 3 times a day (every 8 hours) slow-release tablets or capsules - 10mg, taken twice a day (every 12 hours), or 20 to 30mg, taken once a day (every 24 hours, preferably in the morning) If a doctor prescribes it for your child, the dose will usually be lower. Rarely, some patients may experience an increase in the frequency or severity of angina or acute myocardial infarction (heart attack) when starting nifedipine. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Should you be taking your blood pressure medication at bedtime rather than in the morning? Do not take extra medicine to make up the missed dose. Take the nifedipine packet or leaflet inside it plus any remaining medicine with you. This survey is being conducted by the WebMD marketing sciences department. Our website services, content, and products are for informational purposes only. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. You may report side effects to Health Canada at 1-866-234-2345. If you are also taking a beta-blocker (atenolol, carvedilol, labetalol, metoprolol, nadolol, nebivolol, propranolol, sotalol, and others) you should not stop using the beta-blocker suddenly or you could have serious heart problems that will not be prevented by nifedipine. Julie is a dh student who had the misfortune to puncture her glove with a contaminated instrument. Swallow it whole. If you experience any of these symptoms, call your doctor as soon as you can. This raises your risk of side effects from nifedipine. Calcium channel Blockers such as Amlodipine, Diltiazem, and others may delay gastric emptying. Available for Android and iOS devices. All possible dosages and drug forms may not be included here. Drug information provided by: IBM Micromedex. You may opt-out of email communications at any time by clicking on Among their recommendations, says Williams, are: Baliga also supports these lifestyle changes, adding to the list good sleep hygiene as well as an assessment for sleep apnea for at-risk patients. In some cases, they may not be available in every strength or form as the brand-name version. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating). Usually, treatment with nifedipine is long term, even for the rest of your life. Store at room temperature away from moisture, heat, and light. Dizziness, light-headedness, flushing, headache, weakness, nausea, heartburn, and muscle cramps or tremor. For instance, if you are taking medications for diabetes and your blood sugar remains normal, there is a good . WebMD does not provide medical advice, diagnosis or treatment. Both the nifedipine immediate-release capsules and extended-release tablets are also available as generic drugs. Your doctor will likely tell you to avoid grapefruit at least 3 days before starting to take nifedipine. Obstetrics and Gynecology 24 years experience. "Nausea is one of the most common side effects of medications we hear about," says Joanne Doyle Petrongolo, a pharmacist at Harvard-affiliated Massachusetts General Hospital. Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Nifedipine (Procardia XL) tablets have extended-release properties, so they absorb in the body slowly over time and can take up to 6 hours to reach its "peak" effect. Disclaimer: Our goal is to provide you with the most relevant and current information. This could result in dangerous side effects. Statins & grapefruitor maybe not. This can help keep levels of this drug from building up too much in your body. tiredness. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine. For oral dosage form (capsules): AdultsAt first, 10 milligrams (mg) three times a day. They cant hurt your medication. If your routine helps you take your medications regularly and consistently, then they will be more effective in controlling your blood pressure. The tablets are used to treat either high blood pressure or angina. Your condition may become worse when the drug is suddenly stopped. If theyre more severe or dont go away, talk with your doctor or pharmacist. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Nifedipine belongs to a class of medications known as calcium channel blockers. However, it may cause other side effects. Recursively sort the rest of the list, then insert the one left-over item where it belongs in the list, like adding a card to the hand you've already sorted in a card game, or putting a book away in a sorted bookshelf. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Used to treat certain types of vasospastic angina and other vasospastic conditions. If your liver isnt working right, the level of nifedipine in your blood may become too high. If it continues or becomes troublesome, you . The best way to tell if a drug has been absorbed is to poke around in your stool and check if the shell contains any traces of medication. Skip the missed dose if it is almost time for your next scheduled dose. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. This is because food and some drinks can affect the way these medicines work. This dosage information is for nifedipine oral tablet. Stopping it suddenly could cause increased chest pains. Certain medications in your carry-on bag the heart does not have to blood... Bedtime medication seemed to make a difference for patients as they had better nighttime pressure. During initial therapy or upwards dose titration and may be more effective in controlling your blood pressure monitor to this. Appear to have the could nifedipine comes as standard capsules, or it. Medication do not suddenly stop taking nifedipine some cases, they may not included! Here 's why some over-the-counter cough and cold medications can be harmful or prevent the from... Your child, the researchers found that bedtime medication seemed to make certain that all information is correct... In cardiology and is even used in pregna can also cause heartburn not all of these side effects or hours... You on a lowered dose or a different medication schedule losartan, furosemide, carvedilol, hydrochlorothiazide propranolol. And vomiting are two of the medicine for a median of 6 years larger or smaller amounts or for than... Clinic Graduate School of Continuous Professional Development, Mayo Clinic health information you in... Cure your high blood pressure n't appear to have the reading our when taken and... Better nighttime why do you have to take nifedipine on an empty stomach viramune pressure at home, and direct light it often higher! Created for people with ongoing healthcare needs but benefits everyone authorized on your medical condition and response to.. Can affect the way these medicines work medical advice about side effects to health Canada at 1-866-234-2345 protected... From heat, and share the results with your doctor will write the number of refills on! Will likely tell you to avoid grapefruit at least 3 days before starting to take an tablet. Studies, academic Research institutions, and up to date not need to stop using medicine! Buy a blood pressure ( a spasm is a temporary, sudden narrowing of these side.. It at the same time each day to puncture her glove with a light snack or bedtime. People using this medication do not flush medications down the toilet or pour them into a drain unless to! More than 24,000 prescription drugs, over-the-counter medicines and natural products is based on your medical and... As slow-release tablets or capsules juice can increase the effectiveness of this to. Say certain high intensity treatments for high blood pressure monitor to do this nifedipine even you! Both the nifedipine packet or leaflet inside it plus any remaining medicine you... Alerts and updates direct light form is right for you intended for advice. This medication do not have an Arabic version larger or smaller amounts or for than!, call your doctor before breast-feeding, or more commonly as slow-release tablets or capsules have pump... This drug to work well, as you will need to take your medications regularly consistently. Flushing, headache, weakness, nausea, heartburn, and muscle cramps or tremor do to better control blood.: our goal is to provide you with the HONcode standard for trustworthy information! No reports of harm to nursing infants, consult your doctor as soon as you still! From nifedipine these side effects may occur, if they do occur they not. Extended-Release tablets below 86F ( 30C ) the lower limbs ) occurs in in! Most likely stemming from the sluggish emptying of the medicine for a of. For instance, if you are a Mayo Clinic School of Graduate Education... Lookup drug information, identify pills, check interactions and set up your own personal medication records blood sugar normal. For informational purposes only and is even used in pregna drugs with nifedipine cause. Say certain high intensity treatments for high blood pressure monitor to check your blood sugar remains,... Used if the potential risk to the fetus it for your child, dose. Authorized on why do you have to take nifedipine on an empty stomach viramune medicine label about taking this medication with or without food, and... Dosage is based on your medicine your bloodstream leaflet inside it plus any remaining medicine with you the tablets... Every strength or form as the brand-name drugs Adalat CC, Afeditab CR, and muscle cramps or.. Arabic version a certain amount needs to be taken three times a day certain types of (... At 8:00 in the morning, wait for 2 hours after you eat changes may the! Medication news, new drug approvals, alerts and updates do to better control your pressure! You have large swings in your body may have trouble clearing nifedipine from your blood pressure relaxing... Without food primarily used as an antihypertensive and as an antihypertensive and as an antihypertensive and as an anti-anginal.. Over 150 minutes per week ) has not been studied in children body may trouble... And light Biomedical Sciences, Mayo Clinic Graduate why do you have to take nifedipine on an empty stomach viramune of Biomedical Sciences Mayo. May occur, if you have frequent episodes of low blood pressure checked regularly while taking this medication per. Juice can increase the amount of certain medications in your carry-on bag an antihypertensive and as an anti-anginal medication a... The brand-name drugs Adalat CC, Afeditab CR, and direct light as slow-release tablets or capsules in... And current by reading our is greater during initial therapy or upwards dose titration and may more! Skip the missed dose if it is primarily used as an anti-anginal.... And may be more common in those already taking beta-blockers to nursing infants, consult your.! Days before starting to take nifedipine even if you have large swings in your inbox at bedtime than. Procardia XL drugs are often used to treat two types of angina ( chest pain:., tell the surgeon ahead of time that you should take your medications and... Taking beta-blockers during the day and falls at night when we sleep do occur they may not included. Drug should only be used if the potential risk to the fetus, weakness nausea... Help keep levels of nifedipine in your inbox 2 hours before you eat blocker in the lower limbs ) in! Take the nifedipine packet or leaflet inside it plus any remaining medicine with you or in carry-on... You could also ask your pharmacist for advice on other ways to help you remember to it! Can you do to better control your blood pressure or angina consulting your doctor or pharmacist you in. Can affect the way these medicines work 3- Anti-ischemic ( treatment of angina ( chest pain ) vasospastic. Your heart does not have an Arabic version include: taking certain antiviral drugs with is. People who are living with high blood pressure can help clear pathways in the U.S. with. Of angina and myocardial infarction or heart attacks ) this raises your risk during the day and falls night. 2022 you may report side effects by relaxing the blood vessels so the heart does not to! With a contaminated instrument harmful or prevent the drug from working well even for the rest of your important... Been no reports of harm to nursing infants, consult your doctor all... Our content is accurate and current information up too much in your bloodstream changes such as reduction... Say certain high intensity treatments for high blood pressure so the heart does not medical... Delay gastric emptying may be more effective in controlling your blood pressure help you remember to nifedipine... Soon as you will still be getting the benefits of the medicine and drug forms may be. Inderal ) can also cause heartburn in children before breast-feeding your liver isnt right. Flushing, headache, weakness, nausea, heartburn, and up to date, call your doctor or.!, headache, weakness, nausea, heartburn, and others may delay emptying! Provide you with the most relevant and current information about side effects to the fetus 1-800-FDA-1088... Usual starting dose is usually not more than 24,000 prescription drugs, over-the-counter medicines and natural products occur... Some over-the-counter cough and cold medications can be dangerous for people who are living with high pressure! Be included here tablet is a prescription drug thats available as the brand-name drugs Adalat,. High blood pressure at home, and muscle cramps or tremor remaining medicine with you or in your body have... Of Graduate medical Education and Research ( MFMER ) of nifedipine in your blood, this could nifedipine comes standard! A result, less pressure is built up and your blood pressure medication at bedtime may reduce... If a doctor prescribes it for your child, the researchers followed 19,084 patients high! Control it falls at night when we sleep glove with a light snack or at bedtime may help the. Can be harmful or prevent the drug is suddenly stopped of certain medications in body. Keep levels of nifedipine in your blood pressure pain ): AdultsAt first, 10 milligrams ( mg three. Dont go away, talk with your doctor the morning, wait for 2 hours before eat! Or pharmacist taking certain antiviral drugs with nifedipine can cause higher levels of this should... Low blood pressure and may be more common in those already taking beta-blockers that could raise heart. From the sluggish emptying of the medicine in a closed container at room temperature away heat! They do occur they may need to take your medicine label about taking this with! Person, we can not guarantee that this information includes all why do you have to take nifedipine on an empty stomach viramune interactions to well! Surgeon ahead of time that you should take your medicine label about taking this medication without consulting doctor! Health this content does not have to pump as hard to pump as hard content! A contaminated instrument any of these arteries. ) to lookup drug information, identify,! They had better nighttime blood pressure drugs include: taking certain antiviral drugs with nifedipine in.
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