To conduct BD studies, it is necessary to understand regulatory requirements, implementation status, and analytical methods. The short answer is: absolutely not. This assumption was wrong. I highlighted important points for easier reading. Standard studies designed to assess these risks were not performed in compliance with accepted empirical research standards. The attack causes damage to the lining, which results in inflammation. It is a toxin that can cause damage in our body if it gets into circulation. In the case of covid-19 vaccines, regulators accepted biodistribution data from past studies performed with related, mostly unapproved compounds that use the same platform technology. In related news, Dr. Malcolm Kendrick posted an article11 on his website June 3, 2021, in which he discusses the links between the SARS-CoV-2 spike protein and vasculitis, a medical term referring to inflammation (itis) in your vascular system, which is made up of your heart and blood vessels. This review aimed at surveying international and Japanese trends concerning the BD study for CTPs and the following subjects were investigated, which were considered particularly important: 1) comparison of guidelines to understand the regulatory status of BD studies in a global setting; 2) case studies of the BD study using databases to understand its current status in cell therapy; 3) case studies on quantitative polymerase chain reaction (qPCR) used primarily in non-clinical BD studies for CTPs; and 4) survey of imaging methods used for non-clinical and clinical BD studies. No published research data on biodistribution of the mRNA vaccines in animals can be found on the internet. Scientists discovered the SARS-CoV-2 spike protein circulating in the blood of eleven of the thirteen healthcare workers. Explanation: We deem this post as disinformation when it is claimed that the spike protein attacks the ovaries, the neurological system, and other organs. A recent study from the University of Rochester reveals how the biodistribution kinetics and the affinity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for many different organs . Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of MRNA-1273 Vaccine Recipients. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. The Carton Theme by bavotasan.com. Elaborating on the implications of these findings, he remarked: We have known for a long time that the spike protein is a pathogenic protein. which is it, did they or did they now know that the spike protein was a toxin/pathogenic for a long time? Guidelines on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. DO NOT forget Japanese biodistribution study looking at lipid nano-particles in rats & how they bio-accumulated in first 48 hours post administration; understand that this links direct to COVID jabs Dr. Byram Bridle was attacked for his work showing that content of the COVID VACCINE did not stay in the injection site (arm) but leeched into the . Read summaries of real world examples of proejcts completed by SGW Designworks. In biodistribution study, two groups of SD rats (15 rats/sex/group) were injected intramuscularly with AdC68-19S 2 10 11 vp (twofold the proposed clinical dose of 1 10 11 vp/dose) or vehicle, respectively, on day 1. According to this study, there was no difference in ovarian function between those who were infected with the Covid-19 and those who were not. I live in Japan. mRNA-1273 . Some people, this gets into circulation, and when that happens, in some people, they can cause damage, especially to the cardiovascular system., https://uncoverdc.com/2021/05/31/vaccine-expert-warns-we-made-a-big-mistake/, In paragraph 3 you quote him as saying inter alia, regarding the spike protein that We thought the spike protein was a great target antigen; we never knew it was a toxin. However, para 8 he states We have known for a long time that the spike protein is a pathogenic protein. So, by vaccinating people we are inadvertently inoculating them with a toxin.. The sections were washed with 50% EtOH (1 min4). 2015 Aug 20;10(8):e0135389. Whats more, TrialSite News reports6 that Pfizer documents submitted to the European Medicines Agency [EMA] reveal the company did not follow industry-standard quality management practices during preclinical toxicology studies as key studies did not meet good laboratory practice (GLP)., Neither reproductive toxicity nor genotoxicity (DNA mutation) studies were performed, both of which are considered critical when developing a new drug or vaccine for human use. No, the Japanese biodistribution study shows nothing of the sort. We wont know the final answers to many questions concerning the mRNA vaccines until at least 2022 or perhaps longer. "Biodistribution" study of mRNA vaccines. See this image and copyright information in PMC. It has been one of the hardest blogs for me to write and why you did not receive a blog last week! The accumulation in the ovaries is shown on the second page. Among many other things, the glycocalyx contains a wide variety of anticoagulant factors, including tissue factor inhibitor, protein C, nitric oxide and antithrombin. The doctor is also a vaccine researcher who was granted $230,000 by the Canadian government in 2020 to research COVID vaccine development. Pingback: 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf. You can view The Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing. But, as you can see below, unlike Bridle, Politifact neglected to go beyond interviewing someone with such a huge stake in the vaccines success. Messenger RNA (mRNA) vaccines for coronavirus disease 2019 (COVID-19) have been widely deployed in the United States and are highly effective at inducing protection against infection and severe disease [].In December 2020, the Food and Drug Administration gave emergency use authorization (EUA) to the mRNA-1273 vaccine (ModernaTX, Inc), as a two 100-g dose regimen 28 days apart. The biodistribution of hybrid nanostructures is a major subject of current nanomedical research. Bookshelf Focus on certified-organic foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria and lysosomes healthy. We do not have all the animal or clinical data needed to completely evaluate long term safety of the mRNA vaccines. In the same way, its quite possible COVID-19 vaccines may promote Parkinsons and other human prion diseases such as Alzheimers. That, of course, is the type that's produced in a living cell by reading off a given stretch of DNA and assembling the matching RNA, after which it goes off on its own to be fed into a ribosome which will assemble proteins based on its code, reading off by three "codon" letters at a time. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines Vaccine Researcher Admits Big Mistake, Says Spike Protein Is Dangerous Toxin.. Brief Summary: The purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of [18F]GTP1 as a tau targeted radiopharmaceutical in healthy Japanese participants. So the Japanese medicines regulator had required Pfizer to do a study where they looked at how the vaccine distributed around the body, in this case of a . Technically, it is not following the mRNA vaccine itself but following where the LNP container-luciferine goes as a surrogate to understanding where the mRNA may go. what does he mean by long time? This means it was an experiment done with an animal model to predict where the vaccine formulation might go when injected into people. Total recovery (% of injected dose) of radiolabeled LNP+modRNA outside the injection site was greatest in the liver (up to 21.5%) and was much less in spleen (1.1%), adrenal glands (0.1%) and ovaries (0.1%). Res Rep Health Eff Inst. (LogOut/ Thus, the absence of safety pharmacology studies is endorsed by the CHMP, Committee for Medicinal Products for Human Use. . Angiotensin II through binding to its type 1 receptors exerts pro-inflammatory, vasoconstrictive, and prothrombotic effects, while angiotensin (17) has opposing effects In addition, angiotensin II increases cytoplasmic and mitochondrial ROS generation leading to oxidative stress. So by vaccinating people, we are inadvertently inoculating them with a toxin.. 2021 The Japanese Society for Regenerative Medicine. Assuming that the spike protein would not enter into the circulatory system was a grave mistake, according to Bridle, who calls the Japanese data clear-cut evidence that the vaccine, and the spike protein produced by it, enters your bloodstream and accumulates in vital organs. The vaccine-induced spike protein does not do this. 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. In the current work, we aimed to investigate the impact of formulation type on biodistribution profile . Human organ radiation dosimetry is shown in Table 2. Thus it appears that SARS-CoV-2 hijacks mitochondrial machinery for its own benefit, including DMV biogenesis. Dr. Bridle, Associate Professor of Viral Immunology at the University of Guelph,received funding to develop a novel vaccine platform and is very much pro-vaccine. Nanoparticles with positively charged surfaces tend to accumulate in the liver, lung, and spleen [ 34 ]. After drying, the sections were exposed to a BAS imaging plate (FUJIFILM, Tokyo, Japan). Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). The mRNA enters your bloodstream and accumulates in a variety of organs, primarily your spleen, bone marrow, liver, adrenal glands and, in women, the ovaries. Background The viral load and tissue distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain important questions. The research examined thirteen young healthcare workers who had received the Moderna vaccine. Biodistribution; Cell therapy product; Imaging; MRI; PET; SPECT; qPCR. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. In what organs can you find the vaccine? The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. The biodistribution was also studied in rats using radiolabeled LNP and luciferase modRNA (study 185350).. Why do we need it. Family threatened, his life threatened. It is necessary to understand their biodistribution. My daughter in law is pregnant and had the vaccine early in her pregnancy. Canadian virologist Byram Bridle, believes anti-Covid vaccines are directly responsible for cardiovascular injury and death as proposed by the first-of-its-kind "biodistribution" study from Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer/BioNTech cause the . 2022 Apr 7;10(4):869. doi: 10.3390/biomedicines10040869. We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. However, a Japanese document of the Pfizer vaccine data showed biodistribution beyond the local injection site, with distribution highest in the ovaries at 48 hours. Instead it stays open and remains attached to the ACE2 receptor, thereby disabling it and causing a host of problems that lead to heart, lung and immune impairment. Support responsible news and fact-based information today! -, Gu E., Chen W.Y., Gu J., Burridge P., Wu J.C. Molecular imaging of stem cells: tracking survival, biodistribution, tumorigenicity, and immunogenicity. 2018;7(1):7886. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. The liver received the highest dose (0.360 mSv/MBq), followed by the gallbladder wall (0.155 mSv/MBq). 2012;2(4):335345. A total of 4,653,566 medical personnel and 5,734,023 people aged 65 and over had received at It can cause damage in our body if it gets into circulation The spike protein on its own is almost entirely responsible for the damage to the cardiovascular system, if it gets into circulation.. Until recently, the opinion has been that these vaccines function like traditional vaccines and remain near the injection site. Labeled, "Pfizer confidential," the study is known as a bio-distribution study that uses luciferase enzymes and radioisotope markers to accurately track the distribution of Pfizer's mRNA LNPs across the body. If your mitochondria are already dysfunctional, the SARS-CoV-2 virus can more easily knock out more mitochondria, resulting in severe illness and death. As The Defender reported June 3, Bridle received a copy of a Japanese biodistribution study which had been kept from the public as a result of a freedom of information request made to the Japanese government for Pfizer data. 8600 Rockville Pike For Vaxzevria, a single-dose intramuscular biodistribution study with AZD1222 in mice (study 514559) was submitted post-authorisation. Remember, the research cited by Bridle at the beginning of this article found the spike protein accumulates in the spleen, among other places. Toxicol Pathol. AAVs) through secretions or excreta from the animal model or patient. This false claim originated from: viral social media post. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Japanese Regulatory Agency study VAX SPIKE PROTEIN concentrates in spleen, liver, adrenals, and ovaries in high concentrations 2nd Study shows breast milk contamination, infants encountering bleeding disorders in the gastrointestinal tract, reveals various cardiovascular and heart problems, Lying to children - Change is Always Possible, 13th June MUST SEE VIDEOS & DOCUMENTS: Based Amy, Vaccine Shedding: The Harm for Those Who Choose NOT to be Vaccinated - The Hollywood Conservative, Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated - TruthMatters.biz, Breaking News Round Up Continues As The Old Traditional Rite Mass & Sacraments Become Restricted By Pope Francis | Traditional Catholics Emerge, A Secular Perspective on Gods Judgment Anonymous, 7/30/21 | pomegranatesandchains, LA School District Mandates COVID Jabs for All Students 12 and Older - Vaccine Effects, Vaccine Shedding: The Harm For Those Who Choose NOT To Be Vaccinated The Courtenay Turner Podcast, Kanye Wests love of Hitler allegedly goes back decades a well-known but well-keptsecret, 5 G Towers Spark Outrage Across New York City Harm shown in studies including cancer, infertility, and injury to fetuses andnewborns, A sneering Candace Owens thanks the Jewish men who promoted her career, by aligning herself with billionaire Anti-Semite Kanye West Rabbi Boteach denounces Prager and Shapiro for continuing to defend the scamartist, Jeffrey Epstein, Bill Clinton, Ghislane Maxwell, George Bush, Eugenics, the WEF, Transhumanism, China and the creation of a new class of slaves | Interview with Whitney WebbVIDEO, How Hitchcocks Documentary Masterpiece on the Holocaust was Censored as a political inconvenience inBritain, Britain Tried to Send Jewish Holocaust Survivors Back to Germany for Internment, Released DocumentsShow, 'Grand Mufti of Jerusalem' Haj Amin Al-Husseini, Organization of Islamic Cooperation (OIC). Following are pages from the Pfizer Covid vaccine biodistribution study referred to above. In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. Image . Theranostics. This is in contrast to current thinking the mRNA vaccine is quickly broken down at its site of injection in the arm implying no distribution to other organs. Is there a translated version to English of the study somewhere we can access? Its very disconcerting. This is a nonprofit education and research site. Nothing whatsoever on this site is monetized, not even the Amazon links. I therefore claim fair use of materials featured here. To find out what is new, check out the above sidebar item, Recently Modified Posts. New posts are added according to date of event in keeping with the timeline theme, NOT the date when they are created. Material is often added to existing posts as well, as more is learned about an event. To make best use of this site, consider using the tags, categories, and search box. Many posts also have a See also, on this site list. For more details about the purpose and style of this site, please see the About page. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. That same research also establishes that the spike protein alone is almost entirely responsible for damage to the cardiovascular system if circulating in the body. The mouse study used three female BALB-c mice per group and luciferase protein expression was determined by in vivo bioluminescence readouts using an In Vivo Imaging System (IVIS) following injection of the luciferase substrate luciferine. No evidence of vaccine-related macroscopic or microscopic findings were found in the ovaries in the repeat-dose toxicity studies (Study 38166 and Study 20GR142), were identified in the DART, Developmental and Reproductive Toxicology, study.*, The bottom line is mRNA Covid vaccines are still considered experimental by the FDA as. Pfizer report_Japanese government.pdf Report ; Share. . The radiolabeling data, measuring distribution to blood, plasma and selected tissues, of IM injection of a single dose of 50 g mRNA over a 48-hour period is considered more sensitive than the bioluminescence method and indicate a broader biodistribution pattern than was observed with bioluminescence. sharing sensitive information, make sure youre on a federal Problems with blood clotting (coagulation) which are also common during COVID-19 disease are also reported. See the post about the approval for details. *, o LNP=LipoNanoParticle which carries the mRNA, o LC-MS/MS is liquid chromatography with tandem mass spectrometry. The biodistribution study obtained by Bridle showed that the lipid nanoparticles in the vaccine did not remain . When I looked up study PF-07302048 (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: However, the EMA referenced study PF-07302048 and its biodistribution results as below: Biodistribution of a LNP-formulated luciferase surrogate reporter: (Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. 1 Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki, Japan. (11 subjects out of 13 had S-protein in blood. Since the mRNA in the vaccines has been modified to spew out very high amounts of spike protein (far greater than that of the actual virus), the risk of excessive buildup in the cytoplasm is high. Confidential pfizer research document Translated from Japanese to English. These new disclosures seem to indicate that the U.S. and other governments are conducting a massive vaccination program with an incompletely characterized experimental vaccine. High Mutational Heterogeneity, and New Mutations in the Human Coagulation Factor V Gene. Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chdeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quintero-del Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. For the first time ever, the Japanese Regulatory Agency recently gave Bridle and several international collaborators access to a study called the Bio-Distribution Study. The groundbreaking research presents scientists with a more reliable understanding of where COVID-19 messenger RNA (mRNA) vaccines travel in the body after being injected. This conclusion was reached by Israeli scientists, who conducted a study that showed that there is no difference in ovarian function between vaccinated and unvaccinated women. They confirmed what I had found. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. Arthritis Care Res (Hoboken). PLoS One. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). At first glance, this information seems relatively straightforward. This analysis is not usually conducted on ex vivo transduced cells. Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. The biodistribution study obtained by Bridle showed lipid nanoparticles from the vaccine did not stay in the deltoid muscle where they were injected as the vaccine's developers claimed would happen, but circulated throughout the body and accumulated in large concentrations in organs and tissues, including the spleen, bone marrow, liver, adrenal Characteristics of Extracellular Vesicles and Preclinical Testing Considerations Prior to Clinical Applications. Federal government websites often end in .gov or .mil. EPA RULE 503 Biosolids (Sludge) Recycling, Dr Stephanie Seneff Presents Roundup, MMR and Autism A Toxic Connection, Dr. Alice Stewart Truth is the Daughter of Time, Truth in Science, Truth in Corporate Research, Dr. Mercola Interviews Dr. Andrew Wakefield, Brian Deers 2004 film on Andrew Wakefield full film, Andrew Wakefield MD California Jam 2016 talk, Vaxxed From Cover Up To Catastrophe full movie, Dr. Brian Hookers official statement regarding William Thompson, CDC Blocks Testimony by Vaccine Whistleblower in Medical Malpractice Case, Anti-Vaccine Doc Vaxxed: A Doctors Film Review, VAXXED Documentary Explored with Filmmakers on Antidote, Dr. Andrew Wakefield response to the measles outbreak in South Wales, Top CDC Whistle Blower: We Were Ordered to Cover Up Vaccine-Autism Link, Merck Announces Appointment of Dr. Julie Gerberding, Robert De Niro speak candidly about VAXXED vaccine documentary, his son, autism NBC 13-04-2016. Low levels of radioactivity were detected in most tissues, with the greatest levels in plasma observed 1-4 hours post-dose. In summary, normally, the spike protein on a virus will collapse on itself and fall into the cell once it attaches to the ACE2 receptor. Universities across Japan are preparing to provide COVID-19 vaccination venues to help accelerate the country's slow inoculation rollout, with government sources saying it is planning to start giving shots at seven state-run schools later this month. After spending 20 hours of research, I found there are no animal biodistribution studies of mRNA vaccines done by Pfizer, Moderna, or J and J published on an internet search. The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. Anyway, the answer to this question unfortunately is that they go pretty much everywhere. The spike protein also travel to your heart, brain and lungs, where bleeding and or blood clots can occur as a result, and is expelled in breast milk. Spike protein does not attack anything, it only aims to activate the immune response, it is not the same as coronavirus spike protein and after vaccination, it is created in a dose 100 thousand times lower than in viral infection. 3 Bioscience & Engineering Laboratory, FUJIFILM Corp., 577 Ushijima, Kaisei-Machi, Ashigarakami-gun, Kanagawa, Japan. This is about as diabolical as it gets. For example, in the development of new compounds for PET ( positron emission tomography) scanning, a radioactive isotope is chemically joined with a peptide (subunit of a protein ). People will continue to gather evidence supporting the vaccine, and people will continue to gather evidence against the vaccine. Find the original research and move on! Remember to check the date when the fact-check you are reading was published before sharing it. Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. (LogOut/ However, information regarding biodistribution of the Pfizer vaccine in animal studies was referenced by the European Medicine Agencys (EMA) review of Pfizers mRNA vaccine data sent to them by Pfizer. Why the confusion? 2015;99(23):99079922. Remember to check the date when the fact-check you are reading was published before sharing it. The study started last September 16, 2020 and the planned end date is March 31, 2022. Japan has administered COVID-19 vaccine doses to more than 10 million people, the Prime Minister's Office said Wednesday, as the country tries to speed up inoculations that are lagging far behind other developed countries. Prior to the study's disclosure, the public was led to believe by regulators and vaccine developers that the . The signal decreased slowly during the first 72 hours and after 6 and 9 days the signals were further weakened to approximately levels of 18 and 7 times the signals obtained from animals injected with buffer control. (LogOut/ Metabolomic studies suggest that SARS-CoV-2 inhibits mitophagy. Multifunctional NP-based technologies with diagnostic and therapeutic functions are being developed for in vivo applications. Whats more, because the RNA code has been enriched with extra guanines (Gs) and cytosines (Cs), and configured as if its a human messenger RNA molecule ready to make protein by adding a polyA tail, the spike proteins RNA sequence in the vaccine looks as if it is part bacteria,17 part human18 and part viral at the same time. In the case of the Pfizer COVID mRNA vaccine, these newly revealed documents raise additional questions about both the genotoxicity and reproductive toxicity risks of this product. 2. o or the biodistribution of a [3H]-Labelled Lipid Nanoparticle-mRNA Formulation (rat study). Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Theres also evidence suggesting the SARS-CoV-2 spike protein may be a prion, which is yet another piece of really bad news, particularly as it pertains to vaccine-induced spike protein. All the animal or clinical data needed to completely evaluate long term safety of the COVID-19 outbreak also on. Absence of safety pharmacology studies is endorsed by the FDA as found on the second shot of! Nothing whatsoever on this site is monetized, not the date when the fact-check you are reading published... 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Accepted empirical research standards min4 ) can be found on the second shot go pretty much.... Healthcare workers who had received the Moderna vaccine from: viral social media post the,. Material is often added to existing posts as well, as more is learned about an event in pregnancy...
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