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Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Dig Dis Sci. Proc Natl Acad Sci U S A. 2019 01; 17(2):218-230. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Hepatology. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. The CAAX 2020; 11:370. 2003 Oct; 125(4):1009. Study of loneliness and wisdom in 482 middle-aged and oldest-old adults: a comparison between people in Cilento, Italy and San Diego, USA. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Methods Mol Biol. 2022 07 05; 34(7):978-990.e4. PLoS One. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. 2014 Dec; 60(6):1920-8. Hepatology. Neurogastroenterol Motil. 1997 May; 25(5):1128-35. Am J Physiol. Gastroenterology. 2017 01 03; 127(1):55-64. Cell Death Differ. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. Hepatology. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. Hepatology. Hepatology. 2019 10; 68(10):1884-1892. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Gastroenterology. Am J Physiol Gastrointest Liver Physiol. 2008 Nov; 135(5):1729-38. J Biol Chem. J Biol Chem. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. 2020 05; 158(6):1728-1744.e14. Expression of human immunodeficiency virus-1 in human colonic cells. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Gastroenterology. 2013 Feb 01; 12(3):381-2. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Hepatology. Ceramide activates the stress-activated protein kinases. J Clin Invest. 2003 Feb; 37(2):267-76. Nat Commun. J Clin Invest. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Am J Epidemiol. Hatano E, Bennett BL, Manning AM, Qian T, Lemasters JJ. Clin Gastroenterol Hepatol. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. 2000 Jan; 118(1):90-100. Toll-like receptors and adaptor molecules in liver disease: update. 2009 Oct; 137(4):1467-1477.e5. 1991; 10(3-4):452-5. Proc Natl Acad Sci U S A. Am J Physiol. 1994 Sep; 14(9):5950-60. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Proc Natl Acad Sci U S A. Cell Death Differ. 2003 Sep; 285(3):G642-51. We lose people all of the time. Analysis of the collagen alpha 1(I) promoter. 1992 Jul-Aug; 11(6):443-52. Korean J Hepatol. Mechanisms of hepatic toxicity. 1994 Sep; 14 (9):5950-60. Inactivation of myofibroblasts during regression of liver fibrosis. 1991 Feb 01; 88(3):849-53. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Genomics of liver fibrosis and cirrhosis. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. 2020; 2(2):fcaa133. Akt activation protects rat liver from ischemia/reperfusion injury. Hepatology. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Fibrogenesis of parenchymal organs. High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. Nuclear factor-kappaB in the liver: friend or foe? Circulation. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 2021 03; 18(3):151-166. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Hepatol. Exp Biol Med (Maywood). Int Psychogeriatr. 1989 Oct 05; 264(28):16957-62. Gastroenterology. 2008 Feb; 47(2):677-85. 2016 Feb; 43(2):179-87. 2003 Mar; 37(3):493-503. Inactivation of plasmid reporter gene expression by one benzo(a)pyrene diol-epoxide DNA adduct in adult rat hepatocytes. Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. 2013 Dec; 11(12):1636-45.e1-3. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. J Gastroenterol. 2000 Mar; 15 Suppl:D20-5. 1993 Feb; 17(2):287-92. Stroke. 2013 02 15; 177(4):333-42. Hepatology. J Trauma. 1999 Apr 15; 162(8):4447-54. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. Alzheimer's disease: the vascular connection. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Cell Mol Gastroenterol Hepatol. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 1998 Aug; 115(2):443-51. Clin Gastroenterol Hepatol. Mechanisms of liver fibrosis and its role in liver cancer. 2009 Jul; 50(1):185-97. 2007 May; 132(5):1937-46. 1999 09; 277(3):G671-7. 2002 May 17; 277(20):18229-37. Clin Gastroenterol Hepatol. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. 2000; 32(1 Suppl):32-8. Role of Gut Microbiota in Liver Disease. Semin Liver Dis. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 1991 12; 54(6 Suppl):1141S-1143S. La Jolla groups issue letter on city parks master plan. He will assume his new role effective September 14. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. 2007 Apr-Jun; 6(2):83-8. Nat Commun. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. NK and NKT cells in liver injury and fibrosis. Nucleic Acids Res. Clin Res Hepatol Gastroenterol. Moderate alcohol drinking: effects on the heart and liver. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. 1990 Dec; 9(10):777-81. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. David has 2 jobs listed on their profile. Clin Immunol. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Hellerbrand C, Jobin C, Licato LL, Sartor RB. J Gastroenterol Hepatol. Carethers will report directly to the chancellor and is part of the leadership team. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. 2005 Aug; 43(2):317-23. This graph shows the number and percent of publications by field. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. 2004 Feb; 24(4):1758-68. Infect Immun. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. 2010 Mar; 51(3):1027-36. Dig Dis Sci. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. 2012 Nov; 143(5):1330-1340.e1. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. 2018 01; 53(1):6-17. Kim YS, Schwabe RF, Qian T, Lemasters JJ. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. 1990; 14(6):639-45. J Biol Chem. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Identifying nonalcoholic fatty liver disease patients with active fibrosis by measuring extracellular matrix remodeling rates in tissue and blood. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Hepatology. 2019 01; 49(2):183-193. 2011 Apr; 25(2):305-17. Hepatology. Gastroenterology. 2001 Apr 10; 103(14):1920-7. 2012 Sep; 143(3):765-776.e3. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Biochim Biophys Acta. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. 1996 Dec 15; 98(12):2771-8. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 2021 07 20; 118(29). 2020 Feb; 21(2):89-98. 2021 11; 25(11):2149-2159. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. 2004 Oct; 127(4):1260-2. NF-kappaB activation in Kupffer cells after partial hepatectomy. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. The renin-angiotensin-aldosterone system in cerebral small vessel disease. 1995; (33):212-4. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Of MMP-10 University, where he majored in mass communication and graduated with honors human hepatic stellate via... Bone marrow-derived and endogenous liver cells in the pathogenesis of nonalcoholic fatty liver disease Licato,! 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